PersonalMentorColleaguesProject JournalFinal Report

Final Report

ABSTRACT

  The study of retrogenes is not only a relevant topic in the evolutionary analysis of gene origin, but also a way of performing genome-wide studies on possible correlations between different species. Existing literature on retrogene detection however, takes advantage of detailed annotations of certain genomes, therefore restricting their domain of application. This is what motivated the development of a generalized pipeline for retrogene detection. We detail the steps and main concepts in building this robust pipeline that, given the cDNA library and the genome database for a specific species, identifies retrogenes. Apart from being built genome-independent, our pipeline can also identify chimeric retrogenes. We also present possible improvements in light of the difficulties encountered in developing such a pipeline.